منابع مشابه
Octagonal Nuclear Pores
Negative staining of isolated nuclear envelopes by phosphotungstate shows that the nuclear pores are octagonal rather than circular. Pores of the same shape and approximately the same width, 663 +/- 5 A, were demonstrated in the newt, Triturus, the frog, Rana, and the starfish, Henricia. The outer and inner diameters of the annulus associated with each pore are respectively greater and less tha...
متن کاملNuclear pores and nuclear assembly.
Communication between the nucleus and cytoplasm occurs through large macromolecular structures, the nuclear pores. Quantitative scanning transmission electron microscopy has estimated the mass of a nuclear pore to be 60 million Daltons in yeast and 120 million Daltons in vertebrates. The past two years were noteworthy in that they saw: 1) the purification of both the yeast and vertebrate nuclea...
متن کاملNot all nuclear pores created equal
T here’s more than one way to make a nuclear pore, as Dultz and Ellenberg show (1). Depending on where they are in the cell cycle, cells change the order in which they put the pore components together and how long the job takes. Cells can therefore follow more than one procedure to build the same complex structure. Cells manufacture new nuclear pores in two situations (2). All pores disassemble...
متن کاملNuclear Pores: David and Goliath in nuclear transport
Ran is the only known member of the Ras superfamily of small GTP-binding proteins to be localized primarily inside the nucleus, and there is considerable evidence that Ran is closely involved in the traffic of macromolecules into and out of the nucleus [1,2]. Ran has been shown to be an essential factor for nuclear import in digitonin-permeabilized cells, and mutant forms of Ran inhibit both pr...
متن کاملSUMO: ligases, isopeptidases and nuclear pores.
Small ubiquitin-related modifier (SUMO) proteins are reversibly coupled to numerous intracellular targets and modulate their interactions, localization, activity or stability. Recent advances in the SUMO field have uncovered the first SUMO E3 ligases and point to a complex family of isopeptidases. SUMO has been linked to many different pathways, including nucleocytoplasmic transport. Modifying ...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1967
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.32.2.391